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From laboratory investigation, modafinil has minimal to no affinity for serotonin or norepinephrine transporters and does in a roundabout way communicate with these programs.[16][144] However, scientific tests have proven that elevated concentrations of norepinephrine and serotonin can happen as an oblique impact pursuing modafinil administration r
studies have shown that binding of modafinil into the dopamine dopamine transporter in the striatum can stop of the reuptake of dopamine resulting in a lift in extracellular dopamine. Modafinil stimulates glutamatergic circuits even though avoiding gamma-aminobutyric acid (GABA).These results recommend that orexin regulates sleep/wakefulness states
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